By Eylül GÜNQuercetin and its effects on endometriosis
By Eylül GÜN
Endometriosis, as a disease characterized by chronic inflammation and fibrosis, could be a potential target for quercetin, a flavonoid found in various foods and botanicals, and a known senolytic agent with many effects including antioxidant, anti-inflammatory, and immune-modulatory properties. Studies…
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Alterations of mitochondrial dynamics in endometriosis
By Eylül GÜN
Mitochondria are known as the batteries of the cell with the ATP that they produce through oxidative phosphorylation. Mitochondrial dynamics are important mechanisms for mitochondria to maintain their integrity by continuously undergoing changes. Mitochondrial fusion is the joining of two…
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By Dr. Youngran ParkMistletoe as a Potential Candidate for Endometriosis Treatment
By Dr. Youngran Park
Endometriosis, one of the common benign gynecologic disorders, is defined as the ectopic presence of endometrial cells outside of the uterine cavity. Although the underlying mechanisms are not fully understood, the most accepted hypothesis is that endometrial cells pass through…
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IL-37 regulates ectopic endometrial stromal cells to prevent endometriosis
By Dr. Youngran Park
Endometriosis has been identified as a chronic inflammatory disease. It has been shown that in the plasma and peritoneal fluid, women with endometriosis exhibit aberrant numbers of immune cells and concentrations of cytokines and chemokines that promote a chronic inflammatory…
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By Kasthuri NairS100A6 May be a Promising Target for Endometriosis Treatments
By Kasthuri Nair
Peng et al., a group primarily from the Zhejiang University Medical College, recently published a paper in Gynecological Endocrinology titled “Upregulation of S100A6 in patients with endometriosis and its role in ectopic endometrial stromal cells.” This paper delineates a study…
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Autophagy in endometriosis
By Dr. Youngran Park
Endometriosis is a common gynecologic disease affecting both fertile (5-10%) and infertile (20-50%) women, and it commonly causes chronic pelvic pain, dysmenorrhea, and infertility. Recent research found that the autophagy exerts a pro-apoptotic effect on normal human endometrial cells and…
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The Role of IL-35 in the Pathogenesis of Endometriosis
By Kasthuri Nair
The molecular mechanism that drives endometriosis remains elusive to this day. Zhang et al believe that interleukin 35 (IL-35) plays a role in the pathogenesis of the disease. Their recent publication in Reproductive Sciences titled “Upregulation of Interleukin 35 in…
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